Does Varicose Vein Cream Work? No, there aren’t any creams available which can help varicose veins. As varicose veins are caused by an underlying problem with the valves inside the veins, this problem needs to be addressed in order to see an improvement from both a symptomatic and cosmetic perspective. If your varicose veins are severe and you have suffered with skin changes, i.e. varicose eczema, you may be prescribed cream to help with this. However, this will not get rid of the varicose veins themselves.